特任教授、博士生导师、中国科学技术大学生命科学与医学部基础医学院。
邮箱:gongn@ustc.edu.cn
教育与科研经历
2024.4-至今 特任教授,中国科学技术大学生命科学与医学部基础医学院
2023.12-2024.4 特任教授,中国科学技术大学合肥微尺度物质科学国家研究中心
2019.9-2023.11 博士后,美国宾夕法尼亚大学(UPenn)生物工程系,(合作导师:Michael Mitchell 教授)
2014.9-2019.7 博士研究生,清华大学化学系(导师:李景虹教授)
国家纳米科学中心(导师:梁兴杰研究员)
2010.9-2014.7 本科,首都医科大学
研究方向
本课题组的研究是一个涉及生物材料、药物递送以及基因、蛋白质和细胞工程的交叉领域。旨在深入理解并提供解决临床问题的基础性理论及策略。我们的关注点涵盖多个临床问题,包括治疗耐受、复发、毒性、副作用等。正在进行的研究项目包括开发新型药物递送平台,以克服癌症免疫疗法中的耐受;通过纳米颗粒设计增强药物递送到深层肿瘤;建立核酸递送平台用于治疗癌症、传染病和代谢性疾病;利用生物材料修改免疫细胞,以实现高效且低毒的细胞疗法;以及探索蛋白质和肽的工程策略以实现安全的肿瘤免疫疗法等。
在研科研项目
国家级青年人才项目(在研,主持,2024-2026)
奖励与荣誉
2023年国家级青年人才项目
2022 年Burroughs Young Investigator Award, 美国生物医学工程学会
2021年北京市自然科学一等奖(第四完成人),北京市人民政府
2020年京博科技优秀博士论文奖,中国化学会/京博科技股份有限公司
2019年中科院院长特别奖,中国科学院
代表性论文
Google scholar: https://scholar.google.com/citations?user=QcuL8SMAAAAJ&hl=en&oi=ao
研究性论文:
N. Gong#, W. Zhong#, M.-G.Alameh#, X. Han, L. Xue, R. El-Mayta, G. Zhao, A. E. Vaughan, Z. Qin, F. Xu, A. G. Hamilton, D. Kim, J. Xu, J. Kim, X. Teng, J. Li, X.-J. Liang, D. Weissman*, W. Guo*, M. J. Mitchell*. Nature Materials, 2024, accept.
N. Gong, X. Han, L. Xue, M. M Billingsley, X. Huang, R. El-Mayta, J. Qin, N. C Sheppard, C. H June, M. J Mitchell*. Nature Biomedical Engineering, 2024, DOI: 10.1038/s41551-023-01147-6
N. Gong#, X. Han#, L. Xue#, R. El-Mayta, A. E. Metzloff, M. M. Billingsley, A. G. Hamilton, M. J. Mitchell*. In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity. Nature Materials, 2023: 1571–1580.
X. Li#, N. Gong#, *, F. Tian, S. Zhang, Y. Zhang, Y. Wang, G. Qing, Y. Wang, F. Li, Y. Xu, L. Zhang, J. Wang, Q. Ni, Y. Gan, C. Gu, H. Jiang, X. Huang, X. Shi, T. Zhang, Y. Wu*, X.-J. Liang*. Suppression of cytokine release syndrome during CAR-T-cell therapy via a subcutaneously injected interleukin-6-adsorbing hydrogel. Nature Biomedical Engineering, 2023: 1129–1141.
N. Gong, Y. Zhang, X. Teng, Y. Wang, S. Huo, G. Qing, Q. Ni, X. Li, J. Wang, X. Ye, T. Zhang, S. Chen, Y. Wang, J. Yu, P. C. Wang, Y. Gan, J. Zhang, M. J. Mitchell, J. Li, X.-J. Liang*. Proton-driven transformable nanovaccine for cancer immunotherapy. Nature Nanotechnology, 2020, 15(12): 1053-1064.
N. Gong, X. Ma, X. Ye, Q. Zhou, X. Chen, X. Tan, S. Yao, S. Huo, T. Zhang, S. Chen, X. Teng, X. Hu, J. Yu, Y. Gan, H. Jiang, J. Li*, X.-J. Liang*, Carbon dot-supported atomically-dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment. Nature Nanotechnology. 2019, 14,379-387.
X. Han#, N. Gong#, L. Xue, M. M. Billingsley, R. El-Mayta, S. J. Shepherd, M.-G. Alameh, D. Weissman, M. J. Mitchell*. Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis. Nature Communications, 2023, 14(1): 75..
Y. Wang#, N. Gong#,*, C. Ma, Y. Zhang, H. Tan, G. Qing, J. Zhang, Y. Wang, J. Wang, S. Chen, X. Li, Q. Ni, Y. Yuan, Y. Gan, J. Chen, F. Li, J. Zhang, C. Ou, Y. Zhao*, X. Liu*, X.-J. Liang*. An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination. Nature Communications, 2021, 12(1): 4964.
S. Huo#,*, N. Gong#, Y. Jiang, F. Chen, H. Guo, Y. Gan, Z. Wang, A. Herrmann, X.-J. Liang*, Self-assembled Gold-DNA NanoSunflowers for Enhanced Cellular uptake and Controlled Gene Silencing. Science Advances. 2019, 5(10): eaaw6264.
L. Xue#, N. Gong#, S.J. Shepherd, X. Xiong, X. Liao, X. Han, G. Zhao, C. Song, X. Huang, H. Zhang, M.S. Padilla, J. Qin, Y. Shi, M.G. Alameh, D.J. Pochan, K. Wang, F. Long, D. Weissman, M.J. Mitchell*. Rational design of bisphosphonate lipid-like materials for mRNA delivery to the bone microenvironment. JACS, 2022, 144(22): 9926-9937.
综述/评论:
N. Gong#, M.-G.Alameh#, R. El-Mayta, L. Xue, D. Weissman*, M. J. Mitchell* Enhancing in situ cancer vaccines using delivery technologies, Nature Reviews Drug Discovery, 2024, accept.
N. Gong, N. C. Sheppard, M. M. Billingsley, C. H. June, M. J. Mitchell*. Nanomaterials for T-cell cancer immunotherapy. Nature Nanotechnology, 2021, 16(1): 25-36.
N. Gong, A. G. Hamilton, M. J. Mitchell*. Exosome-disrupting peptides for cancer immunotherapy. Nature Materials, 2023, 22(5): 530-531.
N. Gong, M. J. Mitchell*. Rerouting nanoparticles to bone marrow via neutrophil hitchhiking. Nature Nanotechnology, 2023, 18, 548-549.
N. Gong, A. G. Hamilton, M. J. Mitchell*. A hydrogel-entrapped live virus immunization. Nature Biomedical Engineering, 2023, 7, 849-850.
N. Gong, M. J. Mitchell*. Lipid nanodiscs give cancer a STING. Nature Materials, 2022, 21(6): 616-617.
招生招聘:
热忱欢迎对生物材料,肿瘤免疫治疗、基因治疗感兴趣的学生前来攻读硕士、博士学位或进行短期,长期交流。欢迎具有药学、肿瘤、化学、生物、医学等背景的博士毕业生进入实验室进行博士后研究工作。感兴趣者请联系课题组长 gongn@ustc.edu.cn。