中国科学技术大学教授，中国科学技术大学附属第一医院（安徽省立医院）副院长、中国科学技术大学附属第一医院西区（安徽省肿瘤医院）院长，主任医师，博士生、博士后导师。入选国家高层次人才特殊支持计划科技创新领军人才、科技部中青年科技创新领军人才、国务院政府特殊津贴、中国肿瘤青年科学家、泰山学者特聘专家等。
主要研究方向为肿瘤个体化精准放射免疫研究。承担863计划、国家科技支撑计划、公益行业科研专项、国家自然科学基金、山东省重点研发计划、自然科学杰出青年基金等十余项，其中为首连续承担7项国家自然科学基金。在肿瘤学、放射治疗及影像学权威期刊等发表论文190余篇，主编著作3部，主持制定全国性肿瘤诊治指南6项，参与制定5项。首位获批国家发明专利23项。3次荣获国家科技进步奖二等奖，为首2次荣获中华医学科技奖、2次荣获省科技进步奖二等奖，多次荣获国际科学奖等十余项。系列研究成果被美国放疗协作组织（RTOG）、美国癌症综合诊治网（NCCN）的肺癌诊治指南（2010-2023）和中国版肺癌临床实践指南采纳，入选美国放射肿瘤学经典教材，获2015 年ASTRO 唯一的 “International Abstract Award” 和2018 年SANTRO “Best Abstract Award”、2020年ASTRO “Best of ASTRO”，2022CSCO创新研究，2023欧洲核医学与分子影像学杂志最佳论文。主持制订放射性食管炎的预防与治疗临床实践指南、放射相关性肺炎中国专家诊治共识等国家级协会指南/共识6部，参与制订中国抗癌协会肺癌诊疗指南（2021/2022版）、中国临床肿瘤学会非小细胞肺癌诊疗指南（2020/2021/2022版）、中国医师协会中国恶性胸膜间皮瘤诊疗指南（2021版）、中国医师协会中国胸腺上皮肿瘤诊疗指南（2021版）等。
研究组主要研究兴趣及方向：
放射肿瘤学、肿瘤学、影像医学与核医学
研究内容：
肿瘤质子治疗
肿瘤精准放疗研究
肿瘤放射免疫的临床和基础研究
分子功能影像指导肿瘤精准诊疗的临床和基础研究
基于人工智能、基因和蛋白组学技术的肿瘤放疗疗效和毒性预测研究
招聘信息：
实验室长期招聘博士后/特任副研究员，欢迎对放射肿瘤学、影像医学与核医学、人工智能和大数据、材料化学等学科具有浓厚研究兴趣的、具备独立研究能力的博士毕业生或者访问学者加入实验室。
联系方式：
Email: yuanshuanghu@sina.com
办公室：中国科学技术大学西校区医算楼610、613
近五年部分代表性学术论文：
近5年以通讯作者发表论文51 篇，累计影响因子 287分，代表性论文如下：
1. Li L, He K, Zhou T, Xu Y, Pang J, Yu Q, Gao Y, Shi H, Zhu H, Li M, Yu J*, Yuan S*. Recurrence/prognosis estimation using a molecularly positive surgical margin-based model calls for alternative curative strategies in pIIIA/N2 NSCLC. Mol Oncol. 2024 Feb 7.
2. Li L, Duan J, Gao Y, Yin Y, Yang F, Tang W, Song X, Hu T, Cui J, Yu J, Yuan S*. Multi-omics predictive model based on clinical, radiomic and genomic features for predicting the response of limited-stage small cell lung cancer to definitive chemoradiotherapy. Clin Transl Med. 2024 Jan;14(1):e1522.
3. Qiao K, Qin X, Fu S, Ren J, Jia J, Hu X, Tao Y, Yuan S*, Wei Y*. Value of [18F]AlF-NOTA-FAPI-04 PET/CT for differential diagnosis of malignant and various inflammatory lung lesions: comparison with [18F]FDG PET/CT. Eur Radiol. 2024 Mar;34(3):1948-1959.
4. Liu J, Yu Q, Wang XS, Shi Q, Wang J, Wang F, Ren S, Jin J, Han B, Zhang W, Su X, Yuan S*, Lin H*. Compound Kushen Injection Reduces Severe Toxicity and Symptom Burden Associated With Curative Radiotherapy in Patients With Lung Cancer. J Natl Compr Canc Netw. 2023 Aug;21(8):821-830.e3.
5. Tao Y, Sun Q, Wei Y, Liang C, Tang S, Li J, Pei J, Li Y, Wang C*, Yuan S*. Early and Accurate Detection of Radiation-induced Heart Damage by Cardiodynamicsgram. J Cardiovasc Transl Res. 2023 Aug 7.
6. He K, Li L, Li A, Xu Y, Pang J, Mu D, Ma J, Ge H, Maleki A, Qin X, Zhang X, Ou Q, Shao Y, Yu J, Yuan S*. Genomic features, evolutionary patterns and minimal residual disease at surgical margins as novel prognostic/predictive biomarkers in locally advanced rectal cancer. Clin Transl Med. 2023 Jun;13(6):e1286.
7. Cui J, Li L, Liu N, Hou W, Dong Y, Yang F, Zhu S, Li J*, Yuan S*. Model integrating CT-based radiomics and genomics for survival prediction in esophageal cancer patients receiving definitive chemoradiotherapy. Biomark Res. 2023 Apr 24;11(1):44.
8. Tao Y, Lu J, Deng W, Ma R, Tang S, Wei Y*, Yuan S*. Correlation of Mean Heart Dose and Cardiac Biomarkers with Electrocardiographic Changes in Patients Receiving Thoracic Radiation Therapy. Radiat Res. 2023 Apr 1;199(4):336-345.
9. Hu X, Zhou T, Ren J, Duan J, Wu H, Liu X, Mu Z, Liu N, Wei Y*, Yuan S*. Response Prediction Using 18F-FAPI-04 PET/CT in Patients with Esophageal Squamous Cell Carcinoma Treated with Concurrent Chemoradiotherapy. J Nucl Med. 2023 Apr;64(4):625-631.
10. Qin X, Bai Y, Zhou S, Shi H, Liu X, Wang S, Wu X, Pang J, Song X, Fan X, Ou Q, Xu Y, Bao H, Li L, Li J, Shao Y, Yuan S*. Early diagnosis of brain metastases using cerebrospinal fluid cell-free DNA-based breakpoint motif and mutational features in lung cancer. Clin Transl Med. 2023 Mar;13(3):e1221.
11. Li L, Sun J, Liu N, Yu R, Zhang J, Pang J, Ou Q, Yin Y, Cui J, Yao X, Zhao R, Shao Y*, Yuan S*, Yu J*. Clinical Outcome-Related Cancer Pathways and Mutational Signatures in Patients With Unresectable Esophageal Squamous Cell Carcinoma Treated With Chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2023 Feb 1;115(2):382-394.
12. Wei Y, Zheng J, Ma L, Liu X, Xu S, Wang S, Pei J, Cheng K*, Yuan S*, Yu J*. [18F]AlF-NOTA-FAPI-04: FAP-targeting specificity, biodistribution, and PET/CT imaging of various cancers. Eur J Nucl Med Mol Imaging. 2022 Mar 9.
13. Wei Y, Cheng K, Fu Z, Zheng J, Mu Z, Zhao C, Liu X, Wang S, Yu J*, Yuan S*. [18F]AlF-NOTA-FAPI-04 PET/CT uptake in metastatic lesions on PET/CT imaging might distinguish different pathological types of lung cancer. Eur J Nucl Med Mol Imaging. 2022 Apr;49(5):1671-1681.
14. Li L, Zheng J, Liu Z, Huang Y, Xiao J, Wang S, Yu Q, Zhang Q, Hu X, Zhao W, Hou W, Spring Kong FM, Yu J, Yuan S*. Pre-treatment 18F-RGD Uptake may Predict Adverse Events during Apatinib Antiangiogenic Therapy. Clin Oncol (R Coll Radiol). 2022 Jun;34(6):e238-e245.
15. Li L, Tang S, Yin JC, Dong L, Yang Z, Liu Y, Ma J, Chang P, Pang J, Bao H, Mu D, Zheng X, Aishajiang R, He K, Zhang S, Ni M, Wu X, Wang X, Shao Y*, Wang J*, Ge H*, Yu J*, Yuan S*. Comprehensive Next-Generation Sequencing Reveals Novel Predictive Biomarkers of Recurrence and Thoracic Toxicity Risks After Chemoradiation Therapy in Limited Stage Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2022 Apr 1;112(5):1165-1176.
16. Yang F, Zhang J, Zhou L, Xia W, Zhang R, Wei H, Feng J, Zhao X, Jian J, Gao X*, Yuan S*. CT-based radiomics signatures can predict the tumor response of non-small cell lung cancer patients treated with first-line chemotherapy and targeted therapy. Eur Radiol. 2021 Sep 26.
17. Li L, Zhao W, Sun X, Liu N, Zhou Y, Luan X, Gao S, Zhao S, Yu J, Yuan S*. F-18-RGD PET/CT imaging reveals characteristics of angiogenesis in non-small cell lung cancer. Transl Lung Cancer Res. 2020 Aug;9(4):1324-1332.
18. He K, Zhang S, Shao L, Yin J, Wu X, Shao Y, Yuan S*, Yu J*. Developing more sensitive genomic approaches to detect radioresponse in precision radiation oncology: From tissue DNA analysis to circulating tumor DNA. Cancer Lett. 2020 Mar 1;472:108-118.
19. Zeng H, Li R, Hu C, Qiu G, Ge H, Yu H, Zhang K, Hu M, Zeng P, Xiao D, Miao C, Wei C, Ni M, Shen J, Li H, Yue J, Lu H, Fan B, Zhu H, Hu X, Kong FS, Yu J*, Yuan S*. Association of twice-daily radiotherapy with subsequent brain metastases in adults with small cell lung cancer. JAMA Netw Open. 2019 May 3;2(5): e190103.
20. Jiang A, Sun W, Zhao F, Wu Z, Shang D, Yu Q, Wang S, Zhu J, Yang F, Yuan S*. Dosimetric evaluation of four whole brain radiation therapy approaches with hippocampus and inner ear avoidance and simultaneous integrated boost for limited brain metastases. Radiation Oncology.2019 Mar 15;14(1):46.
21. Li L, Ma L, Shang D, Liu Z, Yu Q, Wang S, Teng X, Zhang Q, Hu X, Zhao W, Hou W, Jin J, Kong FS, Yu J, Yuan S*. Pretreatment PET/CT imaging of angiogenesis based on 18F-RGD tracer uptake may predict antiangiogenic response. Eur J Nucl Med Mol Imaging. 2019 Apr;46(4):940-947. 2019 Apr;46(4): 940-947.
实验室合照：
