姜浩武

姜浩武

2025-02-14来源:生命科学与医学部


博士生导师。2016年毕业于北京协和医学院获理学博士学位。201411月至201610月,先后以国家公派联合培养博士研究生和助理研究员身份在耶鲁大学医学院从事神经生物学方面的研究。201611月至20251月在圣路易斯华盛顿大学医学院担任博士后和讲师。20251月加入中国科学技术大学生命科学与医学部。相关学术工作以第一作者,共同第一作者和共同通讯作者发表Cell2024 & 2021)、Cell Reports (2023)Nature Communications2019)、Brain, Behavior, and Immunity2019 & 2017)、Journal of Neuroinflammation 2024)等国际知名学术期刊。获授权美国发明专利1 项,国际发明专利PCT 1 项,国家发明专利1项,申请美国专利1项。

初级感觉神经元将有关我们外部环境和内部状态的重要信息传递给中枢神经系统(脑或脊髓),使我们能够检测和感知各种无害和有害的刺激并做出反应。课题组主要研究方向是躯体感觉及产生相应行为反应,尤其是呼吸道反射的神经机制研究。重点关注过敏和感染性疾病,综合运用离体和在体神经电生理技术、 离体和在体钙成像技术、遗传标记的轴突示踪技术、逆向示踪技术,单细胞 PCR 技术、化学遗传学,光遗传学和动物行为学等国际前沿技术手段鉴定和剖析介导喷嚏,咳嗽,疼痛和瘙痒等相关症状的特异性外周感觉受体和神经环路。


代表性论文 (*共同第一作者, #共同通讯作者)

1.  *Jiang H, *Cui H, Chen M, Li F, Shen X, Guo C, Hoekel G, Zhu Y, Han L, Wu K, Holtzman M and Liu Q. Divergent Sensory Pathways of Sneezing and Coughing. Cell.2024 Oct 17;187(21):5981-5997. (Reported by Nature, A Moment of Science …)

2. *Li F, *Jiang H, Shen X, Yang W, Guo C, Wang Z, Xiao M, Cui L, Luo W, Kim BS, Chen Z, Huang AJW, Liu Q. Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem. Cell. 2021 Jul 8:184(14):3762-3773. (Reported by Nature, Nature Reviews  Neuroscience, The Scientist, French science magazine…)

3. *Guo C, *Jiang H, Huang CC, Li F, Olson W, Yang W, Fleming M, Yu G, Hoekel G, Luo W, Liu Q. Pain and Itch Coding Mechanisms of Polymodal Sensory Neurons. Cell Rep. 2023 Nov 28;42(11):113316.

4.*Jiang H, *Cui H, Wang T, Shimada SG, Sun R, Tan Z, Ma C, LaMotte RH. CCL2/CCR2 signaling elicits itch- and pain-like behavior in a murine model of allergic contact dermatitis. Brain Behav Immun. 2019 Aug:80:464-473.

5.*Jiang H, *Shen X, Chen Z, Liu F, Wang T, Xie Y, Ma C. Nociceptive neuronal Fc-gamma receptor I is involved in IgG immune complex induced pain in the rat. Brain Behav Immun. 2017 May:62:351-361.

6. *Li F, *Yang W, *Jiang H, Guo C, Huang AJW, Hu H, Liu Q. TRPV1 activity and substance P release are required for corneal cold nociception. Nat Commun. 2019 Dec 12:10(1):5678.

7.#Sun R, #Jiang H. Border-associated macrophages in the central nervous system. J Neuroinflammation. 2024 Mar 13;21(1):67.

8. #Jiang H, #Sun R. The Potential Role of Intestinal Macrophages in the Gut-Brain Axis. Human Brain, 2024, 3(2): 1-27.

9. Beattie K, Jiang H, Gautam M, MacVittie MK, Miller B, Ma M, Liu Q, Luo W. TRPC3 Antagonizes Pruritus in a Mouse Contact Dermatitis Model. J Invest Dermatol.2022 Apr;142(4):1136-1144.

10. *Huang CC, *Yang W, Guo C, Jiang H, Li F, Xiao M, Davidson S, Yu G, Duan B, Huang T, Huang AJW, Liu Q. Anatomical and functional dichotomy of ocular itch and pain. Nat Med.2018 Aug:24(8):1268-1276.



专利

1. Qin Liu, Haowu Jiang, Huan Cui. Pharmacological blockade of nasal sneeze neurons. United States Patent, WU OTM Case Number: T-020676, 2023 Aug 4.

2. Deng Ning, Jiang Haowu, Kang Zhongkui, Wang Hong, Song Qifang. Anti-bFGF humanized double-stranded antibody with stable disulfide bond, preparation method and application thereof. United States Patent, US9273131 B2, 2016 Mar 1.

3. Deng Ning, Jiang Haowu, Kang Zhongkui, Wang Hong, Song Qifang. Anti-bFGF humanized double-stranded antibody with stable disulfide bond, preparation method and application thereof. The International Patent Cooperation Treaty (PCT), WO 2013/097470 A1, 2013 Jul 4.

4. Deng Ning, Wang Hong, Jiang Haowu, Wang Panpan, Song Qifang, Tang Yong, Huang Jianfang. Antibody Dab-2 against FGF-2 and application thereof. China Patent, CN102617734 B, 2013. 09. 04.



招生招聘:

实验室招聘神经生物学(电生理)、免疫学、分子生物学和成像等相关背景的博士后,技术员和科研助理,待遇从优。

招聘实验室管理员1名,具有实验室管理经验者优先。

同时热忱欢迎对本实验室研究方向感兴趣的本科生前来攻读博士学位。

联系方式:haowu.jiang@ustc.edu.cn


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