主要研究兴趣

1. NK细胞和ILC亚群的发育分化；

2. NK细胞亚群的区域免疫特性；

3. NK细胞亚群在重大疾病中的作用及机制。

彭慧，中国科学技术大学教授，博士生导师，国家优秀青年基金获得者。本科和博士毕业于中国科学技术大学。2012-2019年期间，先后以博士后、副研究员和副教授在中国科学技术大学生命科学学院从事科研教学工作，2019年11月起任生命科学与医学部教授，现任中国科学技术大学生命科学与医学部副部长。长期从事NK细胞研究，致力于解析NK细胞的发育分化、区域免疫特性及其在肿瘤等重大疾病中的作用和机制，发现了肝脏驻留 NK 细胞新亚群，并围绕其谱系发育、功能、疾病意义取得一系列重要进展，以（含共）通讯/第一作者在 Science、Cell、Immunity、Science Immunol、J Exp Med、J Clin Invest、Nat Commu等国际高水平期刊发表论文。主持国家自然科学基金重大研究计划、优青、面上等项目，获国家自然科学二等奖 (排名第三) 、中国免疫学会青年学者奖、海外校友基金会青年教师事业奖，相关成果入选中国血液学十大进展。

代表性论文（*为通讯作者）

Cheng M, Li J, Song J, Song H, Chen Y, Tang H, Wei H, Sun R, Tian Z*, Wang X*, Peng H*. RORα is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis. Cell Rep. 2024;43(2):113786.

Tang F, Li J, Qi L, Liu D, Bo Y, Qin S, Miao Y, Yu K, Hou W, Li J, Peng J, Tian Z, Zhu L*, Peng H*, Wang D*, Zhang Z*. A pan-cancer single-cell panorama of human natural killer cells. Cell. 2023;186(19):4235-4251.

Chen Y, Wang X, Hao X, Li B, Tao W, Zhu S, Qu K, Wei H, Sun R*, Peng H*, Tian Z*. Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions. J Exp Med. 2022;219(5):e20211805.

Song J, Song H, Wei H, Sun R*, Tian Z*, Peng H*. Requirement of RORα for maintenance and antitumor immunity of liver-resident natural killer cells/ILC1s. Hepatology. 2022;75(5):1181-1193.

Bai L, Vienne M, Tang L, Kerdiles Y, Etiennot M, Escalière B, Galluso J, Wei H, Sun R*, Vivier E*, Peng H*, Tian Z*. Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop. Science.2021;371(6536):eaba4177.

Wang X, Tian Z, Peng H*. Tissue-resident memory-like ILCs: innate counterparts of TRM cells. Protein Cell. 2020;11(2):85-96.

Chen Y, Tian Z, Peng H*. Immunological memory: ILC1s come into view. Cell Mol Immunol. 2019;16(12):895-896

Wang B, Zhou J, Chen Y, Wei H, Sun R, Tian Z*, Peng H*. A novel spleen-resident immature NK cell subset and its maturation in a T-bet-dependent manner. J Autoimmun. 2019;105:102307.

Zhou J, Peng H*, Li K, Qu K, Wang B, Wu Y, Ye L, Dong Z, Wei H, Sun R, Tian Z*. Liver-resident NK cells control antiviral activity of hepatic T cells via PD-1/PD-L1 axis. Immunity. 2019;50:403-417.

Bai L, Peng H*, Hao X, Tang L, Sun C, Zheng M, Liu F, Lian Z, Bai L, Wei H, Sun R*, Tian Z*.CD8+ T Cells Promote Maturation of Liver-Resident NK Cells via the CD70-CD27 axis. Hepatology. 2019;70:1804-1815.

Wang X, Peng H*, Cong J, Wang X, Lian Z, Wei H, Sun R*, Tian Z*. Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis. Nat Commun. 2018;9:4854.

Bai L, Peng H*. Generating CD8αα IELs from two sources of thymic precursors. Cell Mol Immunol. 2018;15:640-641. 

Peng H*, Tian Z*. Diversity of tissue-resident NK cells. Semin Immunol. 2017;31:3-10.

Tang L, Peng H*, Zhou J, Chen Y, Wei H, Sun R, Yokoyama WM, Tian Z*. Differential phenotypic and functional properties of liver-resident NK cells and mucosal ILC1s. J Autoimmun. 2016;67:29-35.

Peng H, Tian Z*. Re-examining the origin and function of liver-resident NK cells. Trends Immunol. 2015;36:293-299.

Peng H#, Jiang X#, Chen Y#, Sojka DK, Wei H, Gao X, Sun R, Yokoyama WM, Tian Z*. Liver-resident NK cells confer adaptive immunity in skin-contact inflammation. J Clin Invest. 2013;123:1444-1456.

Peng H, Sun R, Tang L, Wei H, Tian Z*. CD62L is critical for maturation and accumulation of murine hepatic NK cells in response to viral infection. J Immunol. 2013;190(8):4255-62.

联系方式：

办公室电话：63600592;

E-mail: huipeng@ustc.edu.cn.